Acidbase titrations in nonaqueous solvents and solvent. Lithium chloride in non aqueous potentiometric titrations received 26 march 1960 instrument instability is often a problem iu the use of non aqueous solvents in potentiometric measurements or titrations. Acetic acidacetic acid acetic acid slightly ionise and combine both. Fia titrations of phenothiazine derivatives in aqueous micellar. Titrations in nonaqueous solvents discuss the theory, practice, and data on acidic and basic strength of nonaqueous solvents. An assignment on nonaqueous titration of metronidazole tablets in. Sp12 1011 titration of hydrochloric acid with sodium. Nonaqueous titration is the titration of substances dissolved in solvents other than water.
Nonaqueous titration of metronidazole tablets slideshare. Non aqueous titrations is the most titrimetric procedure used in pharmacopoeial assays and serves a double. Indicators are added to the titration medium network analysis by m e van valkenburg pdf free download and show the endpoint of the titration through easily recognizable visual changes like color change, clouding or. The application of titration in nonaqueous media to pharmaceutical analysis. Nonaqueous titrations, types of solvents, perchloric acid, sodium. These sample types can be challenging, but when you. The acidbase determination of different substances by nonaqueous titrations is highly preferred in pharmaceutical analyses since the method is quantitative, exact, and reproducible. This procedure is a very important one in pharmacopoeial assays. Pdf fia titrations of phenothiazine derivatives in aqueous micellar. Thus, the solvents typically used in non aqueous titrations are described above.
Austin peay state university department of chemistry chem 1011 titration of hydrochloric acid with sodium hydroxide revision sp12 rbr page 1 of 7. These solvents combine both properties of protophilic. Non aqueous titration 201701 page 1 of 2 the international pharmacopoeia ninth edition. Non aqueous titrations is the most titrimetric procedure used in pharmacopoeial assays and serves a double purpose, as it suitable for the titration of weak acids and bases and provides a solvent.
The technique is not confined solely to acidbase systems. Pdf nonaqueous titrimetric assay for determination of. Non aqueous titrations are simple and accurate, example. Non aqueous titration refers to a type of titration in which the analyte substance is dissolved in a solvent which does not contain water. This book is organized into three parts encompassing six chapters. The end point in the nonaqueous titrations is determined by the. Non aqueous titration free download as powerpoint presentation. Non aqueous titration definition, theory, and types of. The first part considers the general principles of acids and bases and methods of endpoint determination. Non aqueous titration definition, theory, and types of non. Lithium chloride in nonaqueous potentiometric titrations. The reactions which occur during many nonaqueous titrations can be explained by means of the concepts of the bronstedlowry theory.
The need for non aqueous titration arises because water can behave as a weak base and a weak acid as well, and can hence compete in proton acceptance or proton. Introduction although ph measurements are primarily done on aqueous waterbased samples, there are many ph applications that call for ph measurements and titrations in non aqueous samples or in mixed aqueous non aqueous samples. Flow injection titration basing on the mergingzone technique. A simple, costeffective, rapid, and precise method for determination of loratadine lor in pure and. Thermometric titrations in non aqueous media have a distinct advantage over the analogous aqueous system since all non aqueous systems have a lower specific heat than the corresponding aqueous system. Alternatively, the base b will combine with a proton to yield the conjugate acid hb of the base. The application of titration in nonaqueous media to. Examples of these types of solvents are acetic acid and alcohols. The fia titration method in nonaqueous media based on an official method of determination. Dissolve a quantity of the substance being examined to give an expected titration volume of between 7090% of the burette volume, in 50 ml of dehydrated ethanol r and 5. Application of complexometric titration pdf download.